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Parallume Nanoparticles

Parallel now offers a variety of surface derivitized Parallume nanoparticles with a variety of emitters including Dy (yellow), Eu (red), Er (green), Ho (aqua), Sm (orange) and Tm (blue)

 


The ability to identify the type and location of a particular cellular structure, protein or nucleic acid sequence within a tissue section or cell is indispensable to the definitive diagnosis of many diseases and forms an important central part of pathology. While it very useful to know the types and amounts of various proteins or nucleic acids within a cell or tissue it is even more informative to know the identity of the target molecule and its location within the sample. This is reflected in the expanding use of techniques that provide both molecular and location information such as Immunohistochemistry (IHC) and Fluorescence In Situ Hybridization (FISH). In spite of its central and essential role in medical diagnostics, the analysis of histological specimens is still performed in a serial fashion usually with one stain for one sample. Even more useful information could be obtained from histological samples if dozens of chemically distinct sites, including both nucleic acid and protein-containing regions, could be stained simultaneously - but multiplexing using organic dyes or quantum dots presents several difficulties, such as spectral overlap from broad emission peaks resulting in few codes, instability toward photobleaching, toxicity and a lack of robust surface derivitization chemistry, precludes optical multiplexing beyond a few samples.

Parallel now offers a variety of surface derivitized Parallume nanoparticles with a variety of emitters including Dy (yellow), Eu (red), Er (green), Ho (aqua), Sm (orange) and Tm (blue) and whose spectra are shown below. These nanoparticles are dervitized with a high density of surface carboxylate groups ready for the attachment of your biocontent. Instructions for attaching content to the Parallume nanoparticles are given in the Protocols section of this website. Please Contact Us for additional information.

The following Parallume nanoparticles are available in 1 mL samples.